We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Request for Information (RFI): Strategies for Enhancing Postdoctoral Career Transitions to Promote Faculty Diversity
- Cancer Prevention, Diagnosis, and Treatment Technologies for Low-Resource Settings (R41/R42 - Clinical Trial Optional)
- Cancer Prevention, Diagnosis, and Treatment Technologies for Low-Resource Settings (R43/R44 - Clinical Trial Optional)
- NIOSH Exploratory/Developmental Grant Program (R21)
- K01 Mentored Research Scientist Development Award