We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Opioid Use Disorder in Pregnancy (R01)
- Analyzing and Interpreting Clinician and Patient Adverse Event Data to Better Understand Tolerability (U01)
- Diabetic Foot Consortium - Clinical Research Units (U01)
- Notice of Intent to Publish a Funding Opportunity Announcement for NHLBI Clinical Ancillary Studies (R01)
- New NIH "FORMS-E" Grant Application Instructions Available for Due Dates On or After January 25, 2018